Associations of IGF-1 and IGFBP-3 with aging and the development of age-associated diseases

Aging is a complex biological process impacting various systems of the body, with changes occurring at molecular, cellular, and physiological levels. This review focuses on the role of insulin-like growth factors (IGFs) and insulinlike growth factor-binding proteins (IGFBPs) in aging process. IGF-1 is crucial for the regulation of cell growth, metabolism, and apoptosis, while IGFBP-3 modulates the bioavailability of IGFs by binding to them and influencing their receptor interactions. This article outlines the mechanisms of action of IGF-1 and IGFBP-3 and discusses clinical research findings on their significance in aging, longevity, and the development of age-associated diseases. A literature search was conducted using Scopus and PubMed databases, focusing on fundamental and clinical studies. The search utilized keywords such as «insulin-like growth factors», «insulin-like growth factor-binding proteins», «aging» and «ageassociated diseases».