Dopaminergic therapy disrupts decision‐making in impulsive‐compulsive Parkinsonian patients
Impulsive-compulsive behaviors (ICB) are common non-motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision-making in PD patients with ICB (ICB+) and without it (ICB-), and in healthy controls (HC). Participants performed a risk-based decision-making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk-averting strategy. In DD ON, ICB+ patients (but not ICB- nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision-making.
Authors
- Eleonora Russo (ORCID: https://orcid.org/0000-0002-6215-6305)
- Alberto Arturo Vergani (ORCID: https://orcid.org/0000-0002-6572-0434)
- Chiara Rapallini (ORCID: https://orcid.org/0000-0003-3102-9095)
- Silvia Ramat (ORCID: https://orcid.org/0000-0003-1301-9678)
- Alberto Mazzoni (ORCID: https://orcid.org/0000-0002-9632-1831)
- Ahmet Kaymak (ORCID: https://orcid.org/0000-0003-1239-6359)
- Alessandra Govoni (ORCID: https://orcid.org/0000-0002-5393-5462)
- Luca Caremani
- Aldo Rustichini (ORCID: https://orcid.org/0000-0003-3232-351X)
- Erica Ordali (ORCID: https://orcid.org/0000-0001-7076-3183)
- Fabio Taddeini
- Francesca Piattellini
- Simone Valente
Institutions
- Università di Camerino (IT)
- University of Minnesota (US)
- Scuola Superiore Sant'Anna (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Florence (IT)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1002/acn3.52249
- Citations
- 3
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.92
Funders
- European Commission
- Ministero dell'Università e della Ricerca