Berberine inhibits colorectal liver metastasis via modulation of TGF-β in a cecum transplant mouse model
In conclusion, berberine evidently possess an anti-colon-liver metastatic effect, and its underlying mechanisms involve the inhibition of epithelial-mesenchymal transition (EMT) through the TGF-β signaling pathway. Thus, we cautiously propose the pharmacological potential of berberine in drug research studies targeting hepatic metastasis from CRC.
Authors
- Namhun Lee (ORCID: https://orcid.org/0000-0002-5039-2423)
- Yong-Hwi Kang (ORCID: https://orcid.org/0009-0009-7640-5286)
- Seung‐Ju Hwang (ORCID: https://orcid.org/0000-0003-1037-9133)
- Jing‐Hua Wang (ORCID: https://orcid.org/0000-0002-2034-7429)
- Jin‐Seok Lee (ORCID: https://orcid.org/0000-0002-1046-2132)
- Chang‐Gue Son (ORCID: https://orcid.org/0000-0003-4876-0167)
Institutions
- Daejeon University (KR)
- Daejeon Oriental Hospital (KR)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s40001-024-02122-w
- Citations
- 4
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Research Foundation
- National Research Foundation of Korea