Liver Transplant Beyond the Milan Criteria: Distant Metastases of Hepatocellular Carcinoma (Part II)

Liver transplant is one of the most effective ways to treat hepatocellular carcinoma (HCC). Thanks to the implementation of the Milan criteria, developed almost 30 years ago, 5-year survival rates for patients who underwent a transplant for HCC increased and reached the rates for patients with nontumor indications. Despite the emergence of alternative stratification systems, extrahepatic metastases remain a key contraindication to a liver transplant. Nevertheless, there have been reported cases of liver transplants in spite of the contraindication not only in times of diagnostic limitations but also in the 21st century. We have previously reported our own case of a patient who underwent a liver transplant in spite of pulmonary lesions, which postoperatively were found to be HCC metastases. In this part of the review, we discuss similar cases from the literature. If metastatic lesions are successfully treated, a related donor is available, and other modalities are seen as less preferable in terms of the disease prognosis, a liver transplant may be considered an appropriate way to prolong the patient’s life, although such approach should not be recommended for widespread use.