PRAME Immunostaining in BAP-1-Inactivated Melanocytic Tumors: Unraveling Diagnostic Complexity and Exploring Germline Mutation Associations
The diagnostic complexities of BIMTs necessitate a comprehensive diagnostic strategy. While BAP-1 immunostaining remains pivotal, this study explored PRAME as a potential adjunctive diagnostic tool. PRAME antibody shows highly variable expression in BIMTs, limiting its utility as a supportive tool for the differential diagnosis with melanomas, especially in patients with biphasic lesions and germline mutations in BAP-1.
Authors
- J.J. Ríos-Martín (ORCID: https://orcid.org/0000-0001-6346-0061)
- Jesús Machuca‐Aguado (ORCID: https://orcid.org/0000-0002-2398-209X)
- María Garrido-Ruiz
- Álvaro Gutiérrez-Domingo
- José Luis Rodríguez‐Peralto (ORCID: https://orcid.org/0000-0002-6578-7153)
- Ana López-Prieto
- Rodrigo Mora-Díaz
Institutions
- Research Institute Hospital 12 de Octubre (ES)
- Hospital Universitario Virgen Macarena (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- American Journal of Dermatopathology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1097/dad.0000000000002717
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00