Blood serum interleukins levels and their relationship with colon tissue prostanoids in experimental ulcerative colitis

Conclusions: Results obtained testify the possible role of PGF2α and 8-epi-PGF2α in the development of ulcerative colitis and justify the importance of research on the link of 8-epi-PGF2α, IL-8, PGF2α for understanding the mechanisms of development and progression of this disease. Increasing blood serum IL-8 level may be used as marker of reducing colon tissue COX-1 content in both ethanol- and 2,4-dinitrobenzenesulfonic acid-induced ulcerative colites.