Identification of Potential Inhibitors of Histone Deacetylase 6 Through Virtual Screening and Molecular Dynamics Simulation Approach: Implications in Neurodegenerative Diseases
The study implies that both penfluridol and pimozide have strong and favorable binding with HDAC6, which supports the idea of repositioning these drugs for the management of neurodegenerative disorders. However, further in-depth studies are needed to explore their efficacy and safety in biological systems.
Authors
- Nojood Altwaijry (ORCID: https://orcid.org/0000-0001-7367-8312)
- Anas Shamsi (ORCID: https://orcid.org/0000-0001-7055-7056)
- Azna Zuberi (ORCID: https://orcid.org/0000-0002-3970-4641)
- Moyad Shahwan (ORCID: https://orcid.org/0000-0001-8367-4841)
Institutions
- Northwestern University (US)
- Ajman University (AE)
- King Saud University (SA)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-11-15
- DOI
- https://doi.org/10.3390/ph17111536
- Citations
- 3
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Ajman University