The New Perspectives Journal of Medicine

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by irreversible cognitive decline and pathological changes in the brain.By 2050, it is estimated that 150 million people worldwide will be affected by AD.Although the pathological hallmarks of AD, such as amyloid- plaques and tau protein neurofibrillary tangles, have been extensively studied, the precise cause of AD remains unclear.Moreover, there is significant individual variability in patients' disease progression and symptoms.With the rapid advancement of single-cell sequencing technology, researchers are now able to analyze gene expression at the single-cell level, revealing the complexity and heterogeneity of AD.This paper summarizes the application of single-cell sequencing in AD research, particularly focusing on the functional changes in neurons and glial cells, and discusses its potential for early diagnosis and personalized treatment of AD.