The New Perspectives Journal of Medicine

Combined hepatocellular-cholangiocarcinoma is a rare subtype of primary liver cancer, with as reported incidence between 0.4-14%.The tumor exhibits both hepatocellular carcinoma and intrahepatic cholangiocarcinoma two components.The clinical manifestations are not specific, and it is difficult to make a clear diagnosis before surgery.In this review, we concluded the development of diagnosis, treatment and prognosis about combined hepatocellular-cholangiocarcinoma according to the recent literatures.