PREDICTIVE MARKERS FOR ADVERSE PREGNANCY OUTCOMES: INSIGHTS FROM A PROSPECTIVE COHORT STUDY ON MATERNAL FACTORS, BIOMARKERS, AND UTERINE ARTERY DOPPLER RESULTS

Objective: Effective prediction tools are necessary for better outcomes when it comes to pregnancy-related complications such as intrauterine growth restriction (IUGR), pregnancy-induced hypertension (PIH), and premature birth. In order to improve early risk diagnosis and treatment, this study investigates relationships between maternal variables, first-trimester biomarkers, and second-trimester uterine artery Doppler findings. Methods: Correlations between demographic characteristics, maternal dual test indicators (serum beta-HCG, serum PAPPA), and uterine artery Doppler tests were examined in a prospective cohort study including 500 pregnant women. Statistical studies evaluated correlations with IUGR, PIH, and premature birth. Results: Serum beta-HCG levels below the 5th percentile correlated significantly with preterm birth (RR 2.3131, p = 0.0288). Low serum PAPP-A levels (<5th percentile) associated with PIH (RR 2.1447, p = 0.0204) and IUGR (RR 2.0953, p = 0.0002). Uterine artery Doppler indices (>0.58 RI) demonstrated associations with PIH (RR 2.2448) and IUGR (RR 1.6293). Diastolic notching correlated with preterm birth, PIH, and IUGR. Conclusion: The potential of serum beta-HCG, PAPP-A, and uterine artery Doppler indices as useful predictors of unfavorable pregnancy outcomes is highlighted by this study, which also highlights their use in early risk detection.