Hippocampal volumes in UK Biobank are associated with <i>APOE</i> only in older adults
Apolipoprotein E (<i>APOE</i>) genotype shows an age-dependent association with total hippocampal volume.No association between <i>APOE</i> and total hippocampal volume was detected before age 60.Accelerated decline was observed in ε4/ε4 carriers at age 61 and ε3/ε4 at age 69.Delayed decline was evident in ε2/ε3 carriers starting at age 76.
Authors
- Ariya Chaloemtoem (ORCID: https://orcid.org/0000-0003-0188-2431)
- Sarah M. Hartz (ORCID: https://orcid.org/0000-0002-5429-3799)
- Yoonhoo Chang (ORCID: https://orcid.org/0000-0002-6215-8466)
- Andrey P. Anokhin (ORCID: https://orcid.org/0000-0001-8158-6346)
- Janine Bijsterbosch (ORCID: https://orcid.org/0000-0002-1385-9178)
- Vera Thornton (ORCID: https://orcid.org/0000-0003-4090-4744)
- Laura J. Bierut (ORCID: https://orcid.org/0000-0002-9952-4810)
- Michaël E. Belloy (ORCID: https://orcid.org/0000-0001-7748-9033)
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70024
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Institute of Clinical and Translational Sciences
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Aging
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences