QUATERNIZATION OF CHITOSAN IN DIFFERENT MEDIA AND IMMOBILIZATION OF DRUGS ON QUATERNIZED CHITOSAN

The quaternized chitosan has promising applications in biomedicine as pharmaceuticals and targeted delivery, in gene therapy, tissue engineering, and cosmetology due to the improved solubility and enhancing many biological functions in comparison to the non-quaternized chitosan. The increased demand for such applications is achieved through the beneficial combination of the inherent properties of chitosan with those of quaternized ammonium salts. Various synthesis methods have been developed for the synthesis of quaternary ammonium salts of chitosan. The each of these methods has its own advantages and disadvantages that affect on the product properties. The aim of this work was to choose the optimal ways of to quaternized polymers, and the immobilization of drugs L-thyroxine and doxycycline on its surface. IR spectroscopic analysis showed that the interaction of levothyroxine with chitosan occurs mainly due to hydrogen bonds and orientation forces of intermolecular interaction. IR-spectroscopic analysis of doxycycline also showed that the interaction of drug with chitosan takes place mainly due to hydrogen bonds and orientation forces