In Vitro Kinetic of Glutathione-S-Transferase Enzyme in (Buffalo, Camel, Sheep, Goat, and Cattle) and Inhibition by Aspirin and Paracetamol

Enzyme kinetic showed competitive inhibition pathways for both aspirin and paracetamol. The activity of glutathione-s-transferase of RBCs (buffalo, camel, sheep, goat, and cattle) was measured by the photometric method in the presence and absence of two NSDI analgesic drugs (aspirin and paracetamol). Two different concentrations (10 and 20 mM) of each analgesic drug were used, which covered the reported therapeutic index and toxic concentration range of the drugs. At a level of significance (p < 0.05)