Advancements and clinical applications of extended platelet-rich fibrin (E-PRF)

Extended platelet-rich fibrin (E-PRF) has emerged as a potent biological agent in regenerative medicine and dentistry. It leverages the natural healing capacities of growth factors and cytokines from platelets and leukocytes to promote tissue repair. This systematic review explores the role of E-PRF in various clinical applications, including wound healing, bone regeneration, and periodontal therapy. The findings indicate that E-PRF provides an enhanced bioactive matrix, supporting superior clinical outcomes compared to conventional treatments. Future studies should focus on optimizing E-PRF protocols and investigating its long-term effectiveness.