Assessment of the Additive Effect of Oral Streptomycin with Traditional Regimen Therapy to Eradicate H-Pylori

Recently, an increased incidence of gastrointestinal disorders due to the overgrowth of H. pylori bacteria has been noticed remarkably. One of the clinical manifestations of H. pylori overgrowth is the increased incidence of gastric ulcers. The first line of therapy that is used frequently is triple antibiotic therapy plus gastric reducing agents, notably proton pump inhibitors (P.P.Is). Streptomycin (SM) is an injectable aminoglycoside antibiotic that has enhanced activity on gran-negative microbes. To evaluate the additive effect of SM when used orally on eradicating H. pylori by standard triple therapy. 109 patients were enrolled in this study with a gastroenterologist diagnosed with gastric ulcer caused by H. pylori colonization; 60 patients received triple therapy with oral SM, and the rest received only standard triple therapy. After 14 days of treatment, a urea breath test was done again (after baseline reading), and statistical analysis was performed to evaluate the effect of SM. The Results showed that there was a significant difference in the degree of response to triple therapy plus SM as compared to using triple therapy alone.