A COMPARATIVE STUDY OF SERUM URIC ACID, C-REACTIVE PROTEIN, AND SERUM CALCIUM IN PREECLAMPSIA AND NORMAL PREGNANCY AT SHADAN HOSPITAL

Background: The lack of reliable biochemical markers for accurately diagnosing preeclampsia contributes signicantly to adverse maternal and perinatal outcomes. This study aimed to investigate the relationship between serum uric acid, C-reactive protein (CRP), and serum calcium levels in patients with preeclampsia. Methodology: A prospective case-control study was conducted at Shadan Institute of Medical Sciences, Hyderabad, over a period of 12 months. A total of 84 antenatal women beyond 24 weeks of gestation were enrolled, including 42 with preeclampsia and 42 normotensive controls. Maternal levels of uric acid, calcium, and CRP were compared using independent sample t-tests, and ROC analysis was performed to assess the predictive value for preeclampsia. Results: The mean CRP value (7.22±1.09mg/L) and serum uric acid level (8.79±1.21mg/dL) were signicantly elevated in the preeclamptic group, while serum calcium was notably lower (7.56±1.08mg/dL) compared to normotensive women (p < 0.001*). The area under the curve (AUC) for uric acid was 0.853 (p < 0.001*), demonstrating 73.3% sensitivity and 87.7% specicity. For serum calcium, the AUC was 0.809 (p < 0.001*), with 76.1% sensitivity and 93.1% specicity. When combined, the AUC for all three parameters was 0.919 (p < 0.001*), achieving 100% sensitivity and 86.4% specicity in predicting preeclampsia. Conclusion: Maternal hyperuricemia, elevated CRP, and decreased calcium levels are associated with preeclampsia. The combined assessment of these three biochemical markers provided the highest accuracy for predicting the condition.