Complement activation by <scp>IgM</scp> autoantibodies linked to immune‐mediated neuropathies depends on <scp>C2</scp>
In ex vivo disease models of MMN and AMN, complement activation by IgM autoantibodies from 51 patients was in all cases dependent on C2 and was inhibited by an antihuman C2 antibody. No evidence of a C2 bypass mechanism was found.
Authors
- Elisabeth de Zeeuw (ORCID: https://orcid.org/0009-0005-8665-8747)
- Jeanette H.W. Leusen (ORCID: https://orcid.org/0000-0003-4982-6914)
- Kevin Budding (ORCID: https://orcid.org/0000-0002-3827-7131)
- Monique C. Minnema (ORCID: https://orcid.org/0000-0002-3139-8379)
- Kim Dijkxhoorn (ORCID: https://orcid.org/0009-0005-9692-9360)
- Inge Van de Walle (ORCID: https://orcid.org/0000-0002-7631-399X)
- Lauri M. Bloemenkamp
- Nicolette C. Notermans (ORCID: https://orcid.org/0000-0002-9363-4103)
- W. Ludo van der Pol
- C. Erik Hack
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Argenx (Belgium) (BE)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1111/ene.16541
- Citations
- 3
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.11