Investigating the efficacy of ergothioneine to delay cognitive decline in mild cognitively impaired subjects: A pilot study
Prolonged intake of ergothioneine showed no toxicity in elderly people. Enhanced Rey Auditory Verbal Learning Test performance and stabilized neurofilament light chain levels suggest improvements in memory and learning abilities and a deceleration of neuronal damage, respectively. Our results add to existing data that ergothioneine is safe for extended consumption and may hold the potential to delay cognitive decline in elderly adults.
Authors
- Ee Heok Kua (ORCID: https://orcid.org/0000-0001-5574-0530)
- Richard M. Y. Tang (ORCID: https://orcid.org/0000-0001-8038-1189)
- Christopher Chen (ORCID: https://orcid.org/0000-0002-1047-9225)
- Rathi Mahendran (ORCID: https://orcid.org/0000-0003-4213-7163)
- Barry Halliwell (ORCID: https://orcid.org/0000-0002-3560-7123)
- Lei Feng (ORCID: https://orcid.org/0000-0002-4414-9910)
- Ru Yuan Chua (ORCID: https://orcid.org/0000-0002-9192-2443)
- Irwin K. Cheah (ORCID: https://orcid.org/0000-0001-9817-468X)
- Rachel E.S. Goh
- Jialiang Li (ORCID: https://orcid.org/0000-0002-9704-4135)
- Yu Fung Yau (ORCID: https://orcid.org/0009-0005-5908-2076)
Institutions
- National University of Singapore (SG)
- National University Health System (SG)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1177/13872877241291253
- Citations
- 21
- Primary Topic
- Complementary and Alternative Medicine Studies
- Type
- article
- Field-Weighted Citation Impact
- 15.04
Funders
- Ministry of Health -Singapore
- Ministry of Education - Singapore
- National Medical Research Council