Amyloid-β positivity is less prevalent in cognitively unimpaired <i>KLOTHO</i> KL-VS heterozygotes
KL-VS<sub>HET</sub> is associated with lower odds of being positive for Aβ, regardless of whether one is also positive for tau. Conversely, the likelihood of being tau positive did not differ based on KL-VS genotype. Our findings add to the growing <i>KLOTHO</i> literature and suggests the need for further research focused on understanding the mechanisms underlying KL-VS-related putative resilience to AD.
Authors
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Dena B. Dubal (ORCID: https://orcid.org/0000-0001-7504-4372)
- Julian M. Gaitán (ORCID: https://orcid.org/0000-0001-9552-8921)
- Noah Cook (ORCID: https://orcid.org/0009-0006-7906-5924)
- Gwendlyn Kollmorgen
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Ira Driscoll (ORCID: https://orcid.org/0000-0002-1737-3343)
- Sterling C. Johnson (ORCID: https://orcid.org/0000-0002-8501-545X)
- Cynthia M. Carlsson (ORCID: https://orcid.org/0000-0001-5743-1563)
- Matthew Glittenberg
- Clara Quijano‐Rubio (ORCID: https://orcid.org/0000-0001-9050-3282)
- Ozioma C. Okonkwo (ORCID: https://orcid.org/0009-0009-8764-811X)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Kaj Blennow
Institutions
- Roche (Switzerland) (CH)
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- Sahlgrenska University Hospital (SE)
- Roche Pharma AG (Germany) (DE)
- Geriatric Research Education and Clinical Center (US)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1177/13872877241289785
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Biogen
- Prothena
- Apellis Pharmaceuticals
- Eisai
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Siemens Healthineers
- Julius Clinical
- Avid Radiopharmaceuticals
- Geriatric Research Education and Clinical Center
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke
- NIH Clinical Center