Sexual dimorphism, altered hippocampal glutamatergic neurotransmission, and cognitive impairment in APP knock-in mice
These findings confirm a sex-dependent hyper-to-hypoactivation glutamatergic paradigm in APP<sup>NL-F/NL-F</sup> mice. Further, data illustrate a sexually dimorphic biological aging process resulting in a more severe cognitive phenotype for female APP<sup>NL-F/NL-F</sup> mice than their male counterparts. Research outcomes mirror that of human AD pathology and provide further evidence of divergent AD pathogenesis between sexes.
Authors
- Kevin N. Hascup (ORCID: https://orcid.org/0000-0001-6604-1874)
- Kathleen Quinn
- Samuel McFadden (ORCID: https://orcid.org/0000-0002-2289-5066)
- Erin R. Hascup (ORCID: https://orcid.org/0000-0003-1037-0809)
- Mackenzie R. Peck
- Caleigh A. Findley (ORCID: https://orcid.org/0000-0002-8759-1661)
- Tiarra Hill
Institutions
- Southern Illinois University School of Medicine (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-01
- DOI
- https://doi.org/10.3233/jad-240795
- Citations
- 4
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- National Institutes of Health
- National Institute on Aging