Tuberculosis Preventive Treatment for Pregnant People With HIV in South Africa: A Modeling Analysis of Clinical Benefits and Risks
If APO risks are below identifiable thresholds, TPT during pregnancy could decrease combined maternal and fetal/infant deaths. Given uncertainty around isoniazid's risks, and the low threshold at which APO risks could outweigh benefits from tuberculosis deaths averted, studies of newer TPT regimens among PPWH are warranted to inform guidelines.
Authors
- Jyoti S. Mathad (ORCID: https://orcid.org/0000-0001-9487-7775)
- Emma Kalk (ORCID: https://orcid.org/0000-0001-7706-6866)
- Sylvia M. LaCourse (ORCID: https://orcid.org/0000-0002-9809-5997)
- Acadia M Thielking
- Caitlin M. Dugdale (ORCID: https://orcid.org/0000-0002-6604-6111)
- A. David Paltiel (ORCID: https://orcid.org/0000-0002-4861-3290)
- Robin Wood (ORCID: https://orcid.org/0000-0002-4276-7117)
- Andrea Ciaranello (ORCID: https://orcid.org/0000-0002-4268-3263)
- Krishna P. Reddy (ORCID: https://orcid.org/0000-0002-1832-2193)
- C. Robert Horsburgh (ORCID: https://orcid.org/0000-0001-6838-7895)
- Grace Montepiedra (ORCID: https://orcid.org/0000-0002-6866-4335)
- L. Rosen (ORCID: https://orcid.org/0000-0002-0594-4516)
- Soyeon Kim (ORCID: https://orcid.org/0000-0002-4776-6092)
- Kenneth A. Freedberg (ORCID: https://orcid.org/0000-0003-3143-7822)
Institutions
- Boston University (US)
- NewYork–Presbyterian Hospital (US)
- Harvard University (US)
- Desmond Tutu HIV Foundation (ZA)
- University of Cape Town (ZA)
- University of Washington (US)
- Cornell University (US)
- New York Hospital Queens (US)
- Massachusetts General Hospital (US)
- Presbyterian Hospital (US)
- Health Foundation (GB)
- Center for Global Health (US)
- Frontier Science & Technology Research Foundation, Inc. (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1093/cid/ciae508
- Citations
- 3
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- International Maternal Pediatric Adolescent AIDS Clinical Trials Network
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- Fogarty International Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development