Advantages of next-generation sequencing (NGS) in the molecular classification of endometrial carcinomas – our experience with 270 cases
In comparison with recommended diagnostic algorithms, NGS provides a more reliable classification of EC into particular molecular subgroups. Furthermore, NGS reveals the complex molecular genetic background in individual ECs, which is especially significant within ECs with no specific molecular profile. These data can serve as a springboard for the research of therapeutic programs committed to targeted therapy in this type of tumor.
Authors
- Pavol Slávik (ORCID: https://orcid.org/0000-0002-7712-8964)
- Květoslava Michalová (ORCID: https://orcid.org/0000-0003-3231-6870)
- Michael Michal (ORCID: https://orcid.org/0000-0003-4403-7027)
- Marián Švajdler (ORCID: https://orcid.org/0000-0001-8052-4741)
- Tomáš Vaněček (ORCID: https://orcid.org/0009-0008-5241-9723)
- Ondřej Daum (ORCID: https://orcid.org/0000-0002-0930-7071)
- Jiří Presl (ORCID: https://orcid.org/0000-0001-7632-4069)
- Ondřej Ondič (ORCID: https://orcid.org/0000-0002-4038-5641)
- Petr Holub (ORCID: https://orcid.org/0000-0002-3582-7900)
- Andrea Straková-Peteříková
- Polina Gett
- Nikola Hejhalová
- Adam Hluchý
Publication Details
- Journal
- Česká gynekologie
- Published
- 2024-10-25
- DOI
- https://doi.org/10.48095/cccg2024349
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.57