A single upstream mutation of <i>whiB7</i> underlies amikacin and clarithromycin resistance in <i>Mycobacterium abscessus</i>
Our findings demonstrate the importance of whiB7 in the adaptive stress response in M. abscessus. Moreover, our results highlight the complexity of M. abscessus adapting to drug stress and underscore the need for further research.
Authors
- Cristina Villellas (ORCID: https://orcid.org/0009-0005-9196-5899)
- Jesús Gonzalo‐Asensio (ORCID: https://orcid.org/0000-0001-8841-6593)
- Nacer Lounis
- Jan Michiels (ORCID: https://orcid.org/0000-0001-5829-0897)
- Cuong Vuong (ORCID: https://orcid.org/0000-0001-6125-3245)
- Estefanía Crespo-Yuste
- Natalie Verstraeten (ORCID: https://orcid.org/0000-0002-9548-4647)
- Peter T. Buckley (ORCID: https://orcid.org/0009-0005-1194-3615)
- Kim Thys (ORCID: https://orcid.org/0000-0002-0400-6915)
Institutions
- Janssen (Belgium) (BE)
- Universidad de Zaragoza (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- VIB-KU Leuven Center for Microbiology (BE)
- Instituto de Investigación Sanitaria Aragón (ES)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1093/jambio/lxae286
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Kansas
- Agentschap Innoveren en Ondernemen
- Fonds Wetenschappelijk Onderzoek
- Ministerio de Ciencia e Innovación