Functional analysis of fibroblasts and macrophages in head and neck paragangliomas
Fibroblasts and macrophages are present in the HNPGN tumour microenvironment, and several macrophage and fibroblast functional markers are expressed in HNPGN. Macrophages in HNPGN tissue express metabolic markers MCT1 and MCT4. Further analysis of the fibroblast and macrophage function in HNPGN will improve our understanding of their potential roles in tumour pathogenesis.
Authors
- Jason D. Turner (ORCID: https://orcid.org/0000-0002-5423-5302)
- Paramita Baruah (ORCID: https://orcid.org/0000-0001-6983-6381)
- Ingrid E. Dumitriu (ORCID: https://orcid.org/0000-0002-3076-0911)
- Valentina Pucino (ORCID: https://orcid.org/0000-0002-7683-4568)
- Peter Monksfield (ORCID: https://orcid.org/0000-0001-7343-7105)
- Jennifer L. Marshall (ORCID: https://orcid.org/0000-0002-1727-8290)
- Richard Irving (ORCID: https://orcid.org/0000-0003-0013-719X)
- Meriam Nefla
- Emily Powell (ORCID: https://orcid.org/0000-0002-3482-5209)
- Christopher Dominic Buckley (ORCID: https://orcid.org/0000-0001-6924-6402)
- Adam P. Croft (ORCID: https://orcid.org/0000-0002-9487-0511)
- Sébastien Gilbert (ORCID: https://orcid.org/0000-0003-4357-9553)
- Georgiana Neag (ORCID: https://orcid.org/0000-0002-3087-867X)
- H. Adams
Institutions
- National Health Service (GB)
- University of Leicester (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- University Hospitals of Leicester NHS Trust (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.3389/fendo.2024.1397839
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00