Placental mesenchymal stem cells suppress inflammation and promote M2-like macrophage polarization through the IL-10/STAT3/NLRP3 axis in acute lung injury
The study concluded that pMSCs alleviated lung injury in an LPS-induced ALI model by inhibiting M1 macrophage polarization and proinflammatory factor secretion, while promoting M2 macrophage polarization. This effect was mediated via the IL-10/STAT3/NLRP3 axis, presenting a novel therapeutic pathway for ALI treatment.
Authors
- Songping Xie (ORCID: https://orcid.org/0000-0001-6519-6903)
- Renwei Luo
- Gaoli Liu (ORCID: https://orcid.org/0000-0001-6675-2422)
- Yufei Lei (ORCID: https://orcid.org/0000-0002-5467-3687)
- Haifeng Hu (ORCID: https://orcid.org/0000-0002-4884-323X)
- Wanli Jiang (ORCID: https://orcid.org/0009-0002-7389-9638)
- Zhihao Nie
- Shujian Wei (ORCID: https://orcid.org/0000-0002-5906-5146)
- Qinglu Fan (ORCID: https://orcid.org/0009-0009-9412-9385)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.3389/fimmu.2024.1422355
- Citations
- 13
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province