A prospective multicenter birth cohort in China: pregnancy health atlas

The China Prospective Multi-Center Birth Cohort Study was launched in 2022. In collaboration with medical centers in 12 cities, it aims to establish a high-quality, multidimensional cohort comprising 20,000 natural pregnancy and assisted reproductive families. As of June 26, 2024, 12,911 pregnant women have participated in this study, and 161,122 biological samples have been collected. These samples cover four critical periods (early pregnancy, mid-pregnancy, late pregnancy, and postpartum) and comprise 10 different types such as serum, plasma, and urine. The study has collected comprehensive information from early pregnancy to newborns. The participants have an average age of 29.76 years, an average height of 160.46 cm, an average pre-pregnancy BMI of 23.11, and an average BMI of 27.25 before delivery. The cohort includes individuals from 26 ethnic groups, with 25 minority groups comprising 5.03% of the population. Guizhou Province exhibits the highest percentage of ethnic minorities at 24.96% and Guangdong Province owns the highest proportion (12.22%) of women with two or more children. The prevalence of thalassemia in Guangdong Province is seven times higher than in other provinces. Among pregnant women over 35 years old, the prevalence of gestational diabetes mellitus is twice that of women under 35. Additionally, the prevalence of preeclampsia in women with assisted reproductive pregnancies is more than twice that of those with natural pregnancies. The study extensively collected diverse data and biological samples, making this cohort an ideal candidate for DOHaD field and multi-omics research.

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Publication Details

Journal
European Journal of Epidemiology
Published
2024-11-01
DOI
https://doi.org/10.1007/s10654-024-01157-x
Citations
8
Primary Topic
Pregnancy and preeclampsia studies
Type
article
Field-Weighted Citation Impact
4.66

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article

A prospective multicenter birth cohort in China: pregnancy health atlas

Hanbo Zhang, Yuting Xiang, Fengxiang Wei, Wenzhi Yang et al.
8 citations
European Journal of Epidemiology
Pregnancy and preeclampsia studies
4.66
article

A prospective multicenter birth cohort in China: pregnancy health atlas

Hanbo Zhang, Yuting Xiang, Fengxiang Wei, Wenzhi Yang, Shuzhen Wu, Dan Zheng, Fei Hou, Shihao Zhou, Luming Sun, Xiao Yang, Hongbo Zhai, Lijuan Zheng, Hong Wang, Leilei Wang, Jianguo Zhang, Wenbin Zhang, Niya Zhou, Si Zhou, Jie Gao, Hongbo Qi, Lei Yu, Hua Jin, Liping Guan, Danling Cheng, Lijian Zhao, Jing Yi, Qiaoling Geng, Jun He, Yan Zhou, Qingsong Liu, Siyi Wang
article en
8 citations

Abstract

The China Prospective Multi-Center Birth Cohort Study was launched in 2022. In collaboration with medical centers in 12 cities, it aims to establish a high-quality, multidimensional cohort comprising 20,000 natural pregnancy and assisted reproductive families. As of June 26, 2024, 12,911 pregnant women have participated in this study, and 161,122 biological samples have been collected. These samples cover four critical periods (early pregnancy, mid-pregnancy, late pregnancy, and postpartum) and comprise 10 different types such as serum, plasma, and urine. The study has collected comprehensive information from early pregnancy to newborns. The participants have an average age of 29.76 years, an average height of 160.46 cm, an average pre-pregnancy BMI of 23.11, and an average BMI of 27.25 before delivery. The cohort includes individuals from 26 ethnic groups, with 25 minority groups comprising 5.03% of the population. Guizhou Province exhibits the highest percentage of ethnic minorities at 24.96% and Guangdong Province owns the highest proportion (12.22%) of women with two or more children. The prevalence of thalassemia in Guangdong Province is seven times higher than in other provinces. Among pregnant women over 35 years old, the prevalence of gestational diabetes mellitus is twice that of women under 35. Additionally, the prevalence of preeclampsia in women with assisted reproductive pregnancies is more than twice that of those with natural pregnancies. The study extensively collected diverse data and biological samples, making this cohort an ideal candidate for DOHaD field and multi-omics research.

European Journal of EpidemiologyVol. 39(11)
BGI Group (China) (CN), Hebei Medical University (CN), Tongji University (CN), Hunan Normal University (CN), Shijiazhuang University (CN), Dongguan University of Technology (CN), Westlake University (CN), Shantou University (CN), Chengdu Women's and Children's Central Hospital (CN), Lianyungang Maternal and Children’s Hospital (CN), Inner Mongolia Autonomous Region Meteorological Bureau (CN), Shantou University Medical College (CN), Dongguan People’s Hospital (CN), Women's Hospital, School of Medicine, Zhejiang University (CN), Changsha Hospital for Maternal and Child Health Care (CN), Shijiazhuang Yiling Pharmaceutical (China) (CN), Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN), Inner Mongolia Maternal and Child Health (CN), Shanghai First Maternity and Infant Hospital (CN), Shandong Maternal and Child Health Hospital (CN), Children's Hospital of Chongqing Medical University (CN), Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine (CN), Hebei Science and Technology Department (CN), University of Chinese Academy of Sciences (CN), BGI Genomics, Inner Mongolia Medical University (CN), Chongqing Medical University (CN)
Instituto de Ciencia y Tecnología del Distrito Federal, Education Department of Inner Mongolia Autonomous Region, Natural Science Foundation of Hunan Province, Tianjin Municipal Transportation Commission Science and Technology Development Plan Project, Stanford Maternal and Child Health Research Institute, Adaptable and Seamless Technology Transfer Program through Target-Driven R and D
Good health and well-being
Openalex Percentile: Top 5%
Pregnancy and preeclampsia studies
4.66
DOIOpen Access PDFOpenAlex
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