Impact of Permissive Hypercapnia on Postoperative Early Plasma Neurofilament Light Chain in Elderly Patients Undergoing Laparoscopic Surgery: A Prospective, Randomized Controlled Trial
Our results indicate that intraoperative permissive hypercapnia targeting a <i>P</i>aCO<sub>2</sub> of 45-55 mmHg does not significantly influence postoperative early plasma NfL elevation levels in elderly patients undergoing laparoscopic surgery. During general anesthesia, intraoperative permissive hypercapnia might not significantly impact the central nervous system.
Authors
- Xiaoyu Jia (ORCID: https://orcid.org/0000-0002-2118-8984)
- Qinghe Zhou
- Lei Xie (ORCID: https://orcid.org/0009-0005-2191-0999)
- Zhenping Li (ORCID: https://orcid.org/0000-0002-0279-9747)
- Yazhi Xi
- Xue-Lian Wei
Institutions
- Zhejiang Chinese Medical University (CN)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Therapeutics and Clinical Risk Management
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/tcrm.s492456
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Jiaxing University