CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice
Collectively, we demonstrate an unprecedented role for M1 macrophage-derived CXCL11 as an inducer of M1 macrophage polarization to revert the fibrogenic process in mice with PF, which may provide a clinically meaningful benefit.
Authors
- Heesoon Chang
- Dong-Wook Cho
- In‐Sun Hong (ORCID: https://orcid.org/0000-0002-3267-0127)
- Minje Kang
- Haengseok Song (ORCID: https://orcid.org/0000-0002-5027-7310)
- Seok‐Ho Hong (ORCID: https://orcid.org/0000-0003-3372-442X)
- Woojin Kim (ORCID: https://orcid.org/0000-0001-5520-4228)
- Ji Young Kim (ORCID: https://orcid.org/0000-0001-5822-0338)
- Seung‐Joon Lee (ORCID: https://orcid.org/0000-0003-4597-0281)
- Se‐Ran Yang (ORCID: https://orcid.org/0000-0002-2422-213X)
- Suji Jeong (ORCID: https://orcid.org/0000-0003-3335-668X)
- Jung-Yun Choi
- Mira Park
Institutions
- Gachon University (KR)
- Kangwon National University (KR)
- Nongwoo Bio (South Korea) (KR)
- CHA University (KR)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s13578-024-01320-7
- Citations
- 9
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Education, India
- Ministry of Science and ICT, South Korea