Analysis of single-cell RNA sequencing in human oocytes with diminished ovarian reserve uncovers mitochondrial dysregulation and translation deficiency
Transcriptome analysis revealed that DOR oocytes exhibited mitochondrial dysfunction and translational defects, and the PLAG1-IGF2 axis might be a potential contributor for the low quality of DOR oocytes.
Authors
- Zengming Li (ORCID: https://orcid.org/0009-0007-3808-1255)
- Lifeng Tian (ORCID: https://orcid.org/0009-0003-3797-3674)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-3087-4767)
- Xingwu Wu (ORCID: https://orcid.org/0000-0002-2209-1957)
- Leizhen Xia
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6825-5649)
- Xin Li (ORCID: https://orcid.org/0000-0002-6185-5489)
- Peipei Liu (ORCID: https://orcid.org/0000-0003-1218-7362)
- Jing Lu (ORCID: https://orcid.org/0000-0003-3501-1749)
- Jun Tan (ORCID: https://orcid.org/0000-0001-6275-1326)
- Nana Zhang (ORCID: https://orcid.org/0009-0007-8101-3274)
Institutions
- Handan College (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12958-024-01321-8
- Citations
- 8
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 4.34
Funders
- Jiangxi Provincial Department of Science and Technology
- Wu Jieping Medical Foundation