Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET
Our study expands the knowledge of the differences in cellular composition of gonadotroph and lactotroph PitNET subtypes. It lays the foundation for further studies on the influence of lymphoid cells on the variable aggressive behavior of PitNET. Regarding the treatment of drug-resistant lactotroph PitNET, proliferative lymphocytes, CD8<sup>+</sup> T, and NK cells could represent potentially valuable targets for developing new cancer immunotherapies.
Authors
- Matthias Dottermusch (ORCID: https://orcid.org/0000-0002-9769-7080)
- Martin Dugas (ORCID: https://orcid.org/0000-0001-9740-0788)
- Wolfgang Hartmann (ORCID: https://orcid.org/0000-0002-7609-5021)
- Thomas Albert (ORCID: https://orcid.org/0000-0002-2488-0706)
- Eric Suero Molina (ORCID: https://orcid.org/0000-0001-5652-2105)
- Lea Altendorf (ORCID: https://orcid.org/0009-0002-9426-6944)
- Kornelius Kerl (ORCID: https://orcid.org/0000-0002-5676-8102)
- Christian Seitz (ORCID: https://orcid.org/0000-0002-0520-7866)
- Sophia Scheuermann (ORCID: https://orcid.org/0000-0003-0487-2773)
- Walter Stummer (ORCID: https://orcid.org/0000-0002-3460-0640)
- Ulrich Schüller (ORCID: https://orcid.org/0000-0002-8731-1121)
- Daniela Jeising
- Daniel Münter (ORCID: https://orcid.org/0000-0001-8823-0238)
- Archana Verma
- Carolin Walter (ORCID: https://orcid.org/0000-0002-5155-7728)
- T. Elise Potthoff
Institutions
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University of Münster (DE)
- University Hospital Heidelberg (DE)
- University Hospital Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Kinderkrebs-Zentrum Hamburg (DE)
- University Children's Hospital Tübingen (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12967-024-05821-4
- Citations
- 3
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Deutsche Krebshilfe