Tetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway
A regulatory effect of TMP on the NRF2/ARE pathway was found in both <i>in vitro</i> and <i>in vivo</i> experiments. It promotes the transcription and translation of iron metabolizing and antioxidant molecules. Our study explored the inhibitory effect of TMP on ferroptosis from the iron metabolism pathway and provided new ideas for the treatment of SCI.
Authors
- Jingya Zhou
- Xiaohong Mu (ORCID: https://orcid.org/0000-0002-0075-2320)
- Lin Xu (ORCID: https://orcid.org/0000-0002-9593-3035)
- Jingwei Tao
- Hanjie Zhu (ORCID: https://orcid.org/0000-0002-1204-9843)
- Xiao Fan (ORCID: https://orcid.org/0000-0001-5147-6701)
- Jie Yang (ORCID: https://orcid.org/0000-0002-0276-777X)
Institutions
- Qingdao University (CN)
- Zhejiang Chinese Medical University (CN)
- Beijing University of Chinese Medicine (CN)
- Shaoxing University (CN)
- Qingdao Municipal Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.3389/fphar.2024.1503064
- Citations
- 9
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China
- Beijing University of Chinese Medicine