Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs
<i>G</i>. <i>lucidum</i> displayed broad inhibitory effects on CYPs, with triterpenoids as the main bioactive constituents, which may induce potential drug-drug interaction. This information should be helpful for the rational use of <i>G</i>. <i>lucidum</i> in promoting human health.
Authors
- Chaoyan Han
- Jian Zhou (ORCID: https://orcid.org/0000-0001-7800-881X)
- Dawei Li (ORCID: https://orcid.org/0000-0003-4133-1263)
- Chao Wang (ORCID: https://orcid.org/0000-0002-6251-7908)
- Guixin Zhang (ORCID: https://orcid.org/0000-0002-6171-394X)
- Yuxin Lin (ORCID: https://orcid.org/0000-0002-4509-7657)
- Peng Cao (ORCID: https://orcid.org/0000-0001-7228-3511)
- Xia Lv (ORCID: https://orcid.org/0000-0003-0509-7975)
- Aijing Leng
- Yuzhuo Wu (ORCID: https://orcid.org/0009-0008-1865-6653)
Institutions
- Nanchang University (CN)
- Dalian Medical University (CN)
- Wuhan Wudong Hospital (CN)
- General Hospital of Shenyang Military Region (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.3389/fphar.2024.1485209
- Citations
- 4
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Natural Science Foundation of China
- Dalian Medical University
- Dalian Science and Technology Innovation Fund