Histopathological and Immunohistochemical Investigation on Effects of Boric Acid Used in Treatment of Rats with Knee Osteoartritis on Kidney Tissues

Osteoarthritis (OA) is a disease that often occurs in the knee joints and is characterized by disruption of cartilage homeostasis. Due to the systemic inflammation it creates, it affects not only the joint area, but also many tissues and organs. In this study, the damage caused by systemic inflammatory reactions due to OA in kidney tissue and the protective effect of boric acid were investigated. Wistar albino rats were used in the study. An experimental knee OA model was created by intraarticular injection of monosodium iodoacetate (MIA) in rats. It was formed from 4 groups as Control, OA, OA + 4 mg Boric Acid, OA + 10 mg Boric Acid to work. At the end of the study, kidney tissues were taken from the rats and TNF-α, IL-1β, NOS2 and MMP13 analyzes were performed by histopathological and immunohistochemical methods. Histopathological examinations revealed severe degenerative and necrotic changes in tubular epithelial cells in the OA groups, and these changes decreased in the boric acid-administered group depending on the dose. In immunohistochemical analyzes, it was determined that systemic inflammatory reactions occurring in OA application decreased in a dose-dependent manner with boric acid application. In conclusion; It was determined that kidney tissues were damaged due to systemic inflammatory reactions in rats with OA and boric acid had a protective effect against this damage.