Research on the TSPAN6 regulating the secretion of ADSCs-Exos through syntenin-1 and promoting wound healing
TSPAN6 stimulates exosome secretion and formation, as well as the creation of MVBs and ILVs in ADSCs. Syntenin-1 is essential for TSPAN6's stimulation of ADSCs-Exos secretion. Furthermore, ADSCs<sup>TSPAN6+</sup>-Exos has a greater ability to support wound healing, angiogenesis, and the proliferation and migration of a variety of cells.
Authors
- Zhihua Qiao
- Hongli Zhao (ORCID: https://orcid.org/0000-0002-7426-4928)
- Xiancheng Wang (ORCID: https://orcid.org/0000-0001-8115-3962)
- Weiliang Zeng
- Yiwen Deng (ORCID: https://orcid.org/0000-0002-6618-9155)
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-6396-817X)
- Yunzhu Chen (ORCID: https://orcid.org/0009-0004-2282-9677)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s13287-024-04004-8
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China