Role of the CTCF/p300 axis in osteochondrogenic-like differentiation of polyploid giant cancer cells with daughter cells
CTCF, in synergy with H3K27ac, amplified the expression of P300, facilitating acetyl group transfer to RUNX2. This acetylation stabilized RUNX2 and promoted osteo/chondrogenic differentiation, thereby reducing the incidence of PDC malignancies.
Authors
- Yidi Ning
- Xiaohui Yang (ORCID: https://orcid.org/0000-0001-5175-5209)
- Jie Sun (ORCID: https://orcid.org/0000-0002-5642-0560)
- Jing Xu (ORCID: https://orcid.org/0000-0003-0847-4510)
- Shiwu Zhang (ORCID: https://orcid.org/0000-0002-5052-2283)
- Jiangping Wang
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Union Hospital (HK)
- Nankai University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12964-024-01933-y
- Citations
- 6
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Science Foundation
- National Natural Science Foundation of China