The prefrontal cortex, but not the medial temporal lobe, is associated with episodic memory in middle-aged persons with HIV
Episodic memory was associated with prefrontal structures, and MTL and prefrontal structures did not predict memory decline. There was relative stability in memory over time. Findings suggest that episodic memory is more related to frontal structures, rather than encroaching AD pathology, in middle-aged PWH. Additional research should clarify if recognition is useful clinically to differentiate aMCI and HAND.
Authors
- Susan Morgello (ORCID: https://orcid.org/0000-0001-7729-245X)
- Scott Letendre (ORCID: https://orcid.org/0000-0003-3490-4975)
- Payal Patel (ORCID: https://orcid.org/0000-0002-2984-9484)
- Christine Fennema‐Notestine (ORCID: https://orcid.org/0000-0002-6527-6361)
- Erin E. Sundermann (ORCID: https://orcid.org/0000-0001-5821-8035)
- Paul E. Gilbert (ORCID: https://orcid.org/0000-0003-2769-0294)
- Ronald J. Ellis (ORCID: https://orcid.org/0000-0003-4931-752X)
- David J. Moore (ORCID: https://orcid.org/0000-0001-9699-318X)
- Averi Barrett (ORCID: https://orcid.org/0000-0002-7316-3412)
- Raeanne Cristine Moore (ORCID: https://orcid.org/0000-0002-7499-041X)
- Mark W. Bondi (ORCID: https://orcid.org/0000-0002-1742-3451)
- Laura M. Campbell (ORCID: https://orcid.org/0000-0001-9790-1603)
- Donald Franklin (ORCID: https://orcid.org/0000-0002-6639-8686)
- Robert K. Heaton (ORCID: https://orcid.org/0000-0002-6664-8016)
- Scott C. Roesch (ORCID: https://orcid.org/0000-0001-6574-1916)
- Igor Grant
- Benjamin B. Gelman
Institutions
- University of Washington (US)
- San Diego State University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- The University of Texas Medical Branch at Galveston (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of the International Neuropsychological Society
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1017/s1355617724000596
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- San Diego State University
- University of Washington
- Johns Hopkins University
- National Institutes of Health
- University of California, San Diego