Chronic implantable flexible serpentine probe reveals impaired spatial coding of place cells in epilepsy
The development of minimally invasive and reliable electrode probes for neural signal recording is crucial for advancing neuroscience and treating major brain disorders. Flexible neural probes offer superior long-term recording capabilities over traditional rigid probes. This study introduces a parylene-based serpentine electrode probe for stable, long-term neural monitoring. Inspired by the flexibility and morphology of snakes, the serpentine design of the probe ensures stable anchorage within the brain tissue during subject movement. The probe features a hydrophilic surface and is combined with a biodegradable silk fibroin-polyethylene glycol coating, significantly enhancing biocompatibility and mitigating inflammatory responses. <i>In vivo</i> experiments demonstrate that these probes enable stable, high-quality neural recordings for >8 months. The probes are also used to investigate the neural bases of epilepsy-induced cognitive deficits. By analysing place-cell dynamics in mice pre- and post-epileptic events, we identified the correlation between impaired spatial encoding and the observed cognitive deficits in epileptic mice. This study highlights the potential of our flexible probes in neurological research and medical applications.
Authors
- Yaoyao Liu (ORCID: https://orcid.org/0009-0009-5775-101X)
- Jinping Luo (ORCID: https://orcid.org/0000-0002-7900-9512)
- Mixia Wang (ORCID: https://orcid.org/0000-0002-1310-8075)
- Shiya Lv (ORCID: https://orcid.org/0000-0001-7412-9294)
- Wei Xu (ORCID: https://orcid.org/0000-0003-0987-2481)
- Qianli Jia
- Yimin Duan (ORCID: https://orcid.org/0000-0002-2675-3524)
- Luyi Jing (ORCID: https://orcid.org/0000-0001-9795-4617)
- Gucheng Yang (ORCID: https://orcid.org/0000-0002-9743-8273)
- Zhaojie Xu (ORCID: https://orcid.org/0000-0001-9512-314X)
- Ming Li (ORCID: https://orcid.org/0000-0002-7279-2460)
- Juntao Liu (ORCID: https://orcid.org/0000-0002-5368-398X)
- Fan Mo (ORCID: https://orcid.org/0000-0002-0881-0062)
- Yilin Song (ORCID: https://orcid.org/0000-0001-7756-5139)
- Yirong Wu
- Meiqi Han
- Peiyao Jiao
- Jin Shan (ORCID: https://orcid.org/0000-0002-5409-1759)
- Xinxia Cai
- Yu Wang (ORCID: https://orcid.org/0000-0001-6351-6467)
Institutions
- Chinese Academy of Sciences (CN)
- State Key Laboratory of Transducer Technology (CN)
- Aerospace Information Research Institute (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- National Science Review
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1093/nsr/nwae402
- Citations
- 8
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- Social Trends Institute
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China