Histopathological Alterations in Placentas of Severe and Non-Severe Preeclamptic Patients

Preeclampsia is a significant pregnancy complication associated with vascular lesions and trophoblastic invasion, leading to substantial maternal and fetal risks. This study compares histopathological changes in placental structures among severe and non-severe preeclamptic patients. Placental tissues were analyzed, revealing that preeclampsia groups showed notable villous degeneration, increased fibrin deposition, vascular dilatation, congestion, and syncytial node formation. Severe preeclampsia further exhibited intensified hemorrhage and leukocyte infiltration. These findings underscore the link between preeclampsia severity and placental dysfunction, providing insights into the pathological mechanisms affecting perinatal outcomes. Keywords: placenta, preeclampsia, HELLP, histology