THERAPEUTIC OUTCOME OF SODIUM HYALURONATE EYE DROPS COMBINED WITH RECOMBINANT EPIDERMAL GROWTH FACTOR DERIVATIVE EYE DROPS ON POSTOPERATIVE XEROPHTHALMIA

Post-operative xerophthalmia is a frequent complication following eye surgery.This study aimed to assess the effectiveness of sodium hyaluronate (SH) eye drops combined with recombinant human epidermal growth factor (rh-EGF) derivative eye drops in treating this condition.First, the physicochemical properties of SH eye drops, at concentrations of 0.1% and 0.3% were analysed, evaluating viscosity, surface tension, pH and electrical conductivity.A randomised controlled trial was conducted with 85 patients, divided into three groups: Group A (SH eye drops), Group B (rh-EGF eye drops) and Group C (combined SH and rh-EGF eye drops).Postoperative outcomes were assessed using visual acuity, intraocular pressure and the Scale of Quality of Life for Disease with Visual Impairment (SQOL-DVI).Additionally, xerophthalmia severity was evaluated through clinical symptom scoring, Schirmer's test, tear break-up time (BUT), corneal staining and nerve density analysis.Results showed that Group C demonstrated significantly better outcomes compared to Groups A and B, with improved tear secretion, tear film stability, reduced inflammation and enhanced corneal nerve morphology.These findings suggest that combining SH and rh-EGF eye drops offers a more effective treatment for postoperative xerophthalmia, with notable therapeutic benefits in improving patients' ocular health. RezumatXeroftalmia postoperatorie este o complicaie frecvent dup chirurgia ocular.Acest studiu a urmrit s evalueze eficacitatea picturilor oftalmologice de hialuronat de sodiu (SH) combinate cu picturi oftalmologice derivate din factorul de cretere epidermal uman recombinant (rhEGF) n tratarea acestei afeciuni.n primul rnd, au fost analizate proprietile fizico-chimice ale picturilor oftalmice SH la concentraii de 0,1% i 0,3%, evalund vscozitatea, tensiunea superficial, pH-ul i conductivitatea electric.A fost efectuat un studiu controlat randomizat cu 85 de pacieni, mprii n trei grupuri: Grupul A (picturi oculare SH), Grupul B (picturi oculare rhEGF) i Grupul C (picturi oculare combinate SH i rhEGF).Rezultatele postoperatorii au fost evaluate utiliznd acuitatea vizual, presiunea intraocular i Scala de calitate a vieii pentru boala cu deficien vizual (SQOL-DVI).n plus, severitatea xeroftalmiei a fost evaluat prin scorarea simptomelor clinice, testul Schirmer, timpul de rupere a lacrimilor (BUT), colorarea corneei i analiza densitii nervoase.Rezultatele au artat c grupul C a demonstrat rezultate semnificativ mai bune n comparaie cu grupurile A i B, cu secreie lacrimal mbuntit, stabilitate a filmului lacrimal, inflamaie redus i morfologie mbuntit a nervului cornean.Aceste constatri sugereaz c combinarea picturilor oculare SH i rhEGF ofer un tratament mai eficient pentru xeroftalmia postoperatorie, cu beneficii terapeutice notabile n mbuntirea sntii oculare a pacienilor.