THE STATE OF THE MYOCARDIAL NITROOXIDERGIC SYSTEM DURING MODELLING OF DOXORUBICIN-INDUCED CHRONIC HEART FAILURE AND THE ADMINISTRATION OF ΒETA-BLOCKERS OF VARIOUS GENERATIONS

In this study, a 1-(-phenylethyl)-4-amino-1,2,4-triazolium bromide (Hypertril) with -blocker and NO-mimetic properties, which is of interest for the treatment of chronic heart failure (CHF) was examined.The purpose was to study the effect of various -blockers on the indicators of the NO system in a CHF model.CHF was induced with doxorubicin at a cumulative dose of 14 mg/kg in 85 Wistar rats, which were intragastrically administered metoprolol succinate (15 mg/kg), carvedilol (50 mg/kg), bisoprolol (10 mg/kg), nebivolol (10 mg/kg) and Hypertril (3.5 mg/kg).In the heart, the expression of eNOS and iNOS and the concentration of stable metabolites NO, nitrotyrosine and SH groups were determined.Modelling of CHF leads to a decrease in the expression of eNOS and an increase in iNOS and nitrotyrosine, as well as a deficiency of NO and the SH group.Nebivolol, especially Hypertril, had the most pronounced normalising effect on the NO system.The advantage of Hypertril over basic -blockers was revealed. Rezumatn acest studiu, a fost examinat o bromur de 1-(-feniletil)-4-amino-1,2,4-triazoliu (Hypertril) cu proprieti -blocante i NO-mimetice, care prezint interes pentru tratamentul insuficienei cardiace cronice (CHF).S-a studiat efectul diferitelor blocante asupra indicatorilor sistemului NO ntr-un model de CHF.ICC a fost indus cu doxorubicin la o doz cumulativ de 14 mg/kg la 85 de obolani Wistar, crora li s-au administrat intragastric succinat de metoprolol (15 mg/kg), carvedilol (50 mg/kg), bisoprolol (10 mg/kg), nebivolol (10 mg/kg) i Hypertril (3,5 mg/kg).n inim, a fost determinat expresia eNOS i iNOS i concentraia de metabolii stabili NO, nitrotirozin i grupuri SH.Modelul murin de CHF presupune o scdere a expresiei eNOS i la o cretere a iNOS i a nitrotirozinei, precum i la o deficien a NO i a grupului SH.Nebivololul i, n special Hypertril, au avut cel mai pronunat efect modulator asupra sistemului NO.A fost evideniat avantajul Hypertril fa de -blocantele tradiionale.