ADVANCES OF CO-PROCESSED EXCIPIENTS: APPLICABILITY AND FUNCTIONAL CHARACTERISTIC IMPROVEMENTS

The formulation of drug dosage forms is hindered by the scarcity of ideal single-component excipients essential for achieving excellent performance.This necessity requires modification of excipients to improve its functionality and applicability, thereby supporting the manufacturing of dosage forms.One of the effective strategies to develop the excipient is through co-processing two or more excipients, which is classified as physical modification to improve excipients functionality properties with complex interaction that does not occur at simple physical mixture.The physical interaction between those excipients occurs at the subparticle level, promoting the alteration of bulk properties without significant chemical changes.Co-processed excipients result in superior or multifunctional qualities that provide advantages in drug development phase proven by recent scientific studies.Therefore, advancements of co-processed excipients with better pricing are considered valuable to fulfil the increasing demand for low-cost excipients for generics and the growth of novel dosage forms in the future.Consequently, the prospect of coprocessed excipients will still be focal point of research in academics and application in industries since the use of these excipients reduce formulation complexity in the drug development and manufacturing phase. RezumatLipsa excipienilor monocomponeni, eseniali pentru obinerea unei performane terapeutice optime, face ca formularea formelor de dozare a medicamentelor s fie o provocare.Prin urmare, este necesar modificarea excipienilor pentru a le mbunti funcionalitatea i aplicabilitatea, sprijinind astfel fabricarea formelor de dozare.Una dintre strategiile eficiente de dezvoltare a excipienilor este co-procesarea a doi sau mai muli excipieni, interaciune fizic ce are loc la nivelul subparticulelor, ceea ce permite modificri minore ale proprietilor fizice, fr efecte chimice semnificative.Studiile tiinifice recente au demonstrat c excipienii co-procesai capt caliti superioare sau multifuncionale, care ofer avantaje semnificative n faza de dezvoltare a medicamentelor.Abordarea excipienilor co-procesai rmne un subiect de interes n cercetarea i dezvoltarea de medicamente, att n mediul academic, ct i n industrie, datorit costului sczut de producie i al faptului c reduc dificultile ntmpinate n etapa de formulare a medicamentelor.