CONTROLLED RELEASE AND ANTIBACTERIAL EFFICACY OF TETRACYCLINE AND METRONIDAZOLE LOADED PCL NANOWIRES ON ZIRCONIUM SUBSTRATE

This study investigates the controlled release and antibacterial efficacy of tetracycline and metronidazole loaded on polycaprolactone (PCL) nanowires deposited on zirconium (Zr) substrate.The integration of PCL nanowires on Zr substrate offers a novel approach in enhancing the therapeutic effects of antibiotics, particularly against antibiotic-resistant strains.The PCL nanowires serve as an efficient drug delivery system, providing sustained and targeted release of the antibiotics, thereby maintaining therapeutic concentrations at the site of infection.The antibacterial activity of these nanowire-coated substrate was assessed against Escherichia coli and Staphylococcus aureus, demonstrating significant inhibition of bacterial growth.The study highlights the potential of this nanotechnology-based system in improving the efficacy of antimicrobial therapies, especially in the context of medical implants and wound healing. RezumatAcest studiu investigheaz eliberarea controlat i eficacitatea antibacterian a tetraciclinei, respectiv metronidazolului nglobate n nanofibre de policaprolacton (PCL) depuse pe substrat de zirconiu (Zr).nglobarea antibioticelor n nanofibre de PCL depuse pe substrat de Zr ofer o abordare nou pentru mbuntirea efectului terapeutic al antibioticelor, n special mpotriva tulpinilor rezistente la antibiotice.Nanofibrele de PCL servesc ca un sistem eficient de cedare a medicamentelor, oferind eliberare susinut i intit a antibioticelor, meninnd astfel concentraiile terapeutice la locul infeciei.Activitatea antibacterian a acestor antibiotice nglobate n nanofibre a fost evaluat mpotriva Escherichia coli i Staphylococcus aureus, demonstrnd o inhibare semnificativ a creterii bacteriene.Studiul evideniaz potenialul acestui sistem de cedare bazat pe nanotehnologie de a mbunti eficacitatea terapiilor antimicrobiene, n special n contextul implanturilor medicale i al vindecrii rnilor.