AGEs impair osteogenesis in orthodontic force-induced periodontal ligament stem cells through the KDM6B/Wnt self-reinforcing loop
This study elucidates a novel mechanism by which AGEs influence the osteogenic process and antioxidative capacity of PDLSCs through the KDM6B/Wnt self-reinforcing loop under orthodontic force. Targeting the AGE/RAGE pathway or enhancing KDM6B may enhance orthodontic treatments for diabetic patients.
Authors
- Qiaohui Ying
- Yujun Jiang (ORCID: https://orcid.org/0000-0002-2857-2137)
- Ruihan Gao (ORCID: https://orcid.org/0000-0002-9276-1506)
- Changyun Sun (ORCID: https://orcid.org/0000-0002-5715-2705)
- Minqi Li (ORCID: https://orcid.org/0000-0001-9980-1382)
- Yaoguang Zhang (ORCID: https://orcid.org/0000-0002-1024-9454)
- Hongrui Liu (ORCID: https://orcid.org/0000-0003-3185-0887)
- Jie Guo (ORCID: https://orcid.org/0000-0002-5584-5292)
Institutions
- Shandong University (CN)
- Stomatology Hospital (CN)
- Bone Health and Osteoporosis Foundation (US)
- Jining Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s13287-024-04058-8
- Citations
- 15
- Primary Topic
- dental development and anomalies
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province