Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran
In summary, the PopPK model developed in this study was robust and effectively characterized the pharmacokinetics of dabigatran in healthy Chinese adults, demonstrating that both food and ABCB1 genetic variation significantly influence the absorption and plasma concentration levels of dabigatran.
Authors
- Zhuan Yang
- Wen Rui Tan (ORCID: https://orcid.org/0009-0005-4033-2119)
- Jiyu Chen (ORCID: https://orcid.org/0000-0002-7006-6430)
- Yan He (ORCID: https://orcid.org/0000-0003-4357-4082)
- Ying Wang (ORCID: https://orcid.org/0000-0002-9936-2663)
- Na Li (ORCID: https://orcid.org/0000-0002-0404-6431)
- Yan Zeng (ORCID: https://orcid.org/0000-0002-0925-7879)
- Lü Chen (ORCID: https://orcid.org/0000-0002-7512-1865)
- Qin Li (ORCID: https://orcid.org/0000-0002-2470-6089)
- Peng Du (ORCID: https://orcid.org/0000-0002-3466-8020)
- Yan Zhou
- Chen Zeng (ORCID: https://orcid.org/0000-0001-5350-7639)
- Yun Xiong
- Shijing Liu (ORCID: https://orcid.org/0000-0002-9484-5543)
- Lin Liu (ORCID: https://orcid.org/0000-0002-8472-3067)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5975-9781)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.3389/fphar.2024.1454612
- Citations
- 1
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.71