Population pharmacokinetics of rilpivirine following oral administration and long-acting intramuscular injection in real-world people with HIV
Overall, our model-based simulations showed that only approximately 50% of long-acting rilpivirine C<sub>trough</sub> would be above the 50 ng/mL threshold associated with optimal therapeutic response, while approximately 85% of C<sub>trough</sub> would be above the first quartile of concentrations observed in Phase III trials (32 ng/mL).
Authors
- Enos Bernasconi (ORCID: https://orcid.org/0000-0002-9724-8373)
- Susana Alves Saldanha
- Aline Munting (ORCID: https://orcid.org/0009-0006-2577-5912)
- Laurent Arthur Decosterd (ORCID: https://orcid.org/0000-0002-9840-1325)
- Bernard Surial (ORCID: https://orcid.org/0000-0002-1402-974X)
- Paul Thoueille (ORCID: https://orcid.org/0000-0002-2305-4277)
- François R. Girardin (ORCID: https://orcid.org/0000-0002-0842-927X)
- Monia Guidi (ORCID: https://orcid.org/0000-0002-6419-9317)
- Catia Marzolini (ORCID: https://orcid.org/0000-0002-2312-7050)
- Fabian Schaller
- François Veuve
- Alexandra Calmy
- Huldrych F. Günthard (ORCID: https://orcid.org/0000-0002-1142-6723)
- Eva Choong (ORCID: https://orcid.org/0000-0001-6776-4978)
- Matthias Cavassini
- Jessy J. Duran Ramirez (ORCID: https://orcid.org/0000-0001-6657-0688)
- Pilar Ustero (ORCID: https://orcid.org/0000-0001-8491-363X)
- Dominique L. Braun (ORCID: https://orcid.org/0000-0003-4036-1030)
- Andri Rauch (ORCID: https://orcid.org/0000-0001-5297-6062)
- Thierry Buclin (ORCID: https://orcid.org/0000-0003-0639-5536)
- Patrick Schmid (ORCID: https://orcid.org/0000-0003-1978-5082)
- Caroline Di Benedetto
- M Stöckle
- Hansjakob Furrer
Institutions
- University of Geneva (CH)
- University of Bern (CH)
- University of Liverpool (GB)
- University of Basel (CH)
- University of Zurich (CH)
- Kantonsspital St. Gallen (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Ente Ospedaliero Cantonale (CH)
- University Hospital of Zurich (CH)
- University Hospital of Geneva (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.3389/fphar.2024.1437400
- Citations
- 3
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung