Modulation of SRC by SNTB1 activates the Hippo-YAP pathway during colon adenocarcinoma metastasis
This study postulates that SNTB1 interacts with SRC to activate the Hippo-YAP pathway, thereby promoting COAD metastasis. Furthermore, cellular communication with enterocytes promotes EMT, facilitating metastasis. These findings propose novel therapeutic targets for preventing or treating metastatic COAD.
Authors
- Han Dong-yan
- Ruting Xie
- Qiongyi Huang
- Man Pi
- Shuyuan Xian (ORCID: https://orcid.org/0000-0002-4803-2197)
- Jiaqi Song (ORCID: https://orcid.org/0009-0001-0948-0077)
- Zhengyan Chang (ORCID: https://orcid.org/0000-0002-9785-9756)
- Guo Ji (ORCID: https://orcid.org/0000-0001-6060-4066)
- Jinglei Huang
- Runzhi Huang (ORCID: https://orcid.org/0000-0003-2302-7305)
- Zhenyu Li (ORCID: https://orcid.org/0000-0003-1048-657X)
- Jingcheng Zhang (ORCID: https://orcid.org/0000-0002-6339-7661)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12967-024-05548-2
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- National Cancer Institute