GRK2 mediates cisplatin-induced acute liver injury via the modulation of NOX4
GRK2 mediates the development of cisplatin-induced ALI by modulating NOX4 and ER stress. Pharmacological inhibition of GRK2 with CP-25 or paroxetine effectively alleviated ALI. GRK2 can be used as a potential target for the prevention and treatment of liver injury.
Authors
- Jiajie Kuai (ORCID: https://orcid.org/0000-0001-9715-3975)
- Qianlei Wang
- Qing Qing Sun
- Ke Xiao (ORCID: https://orcid.org/0000-0002-0169-4185)
- Wei Wei (ORCID: https://orcid.org/0000-0002-3117-9598)
- Chun Wang (ORCID: https://orcid.org/0009-0009-5110-2086)
- Xiao Feng (ORCID: https://orcid.org/0000-0003-3111-760X)
- Jin Cheng (ORCID: https://orcid.org/0009-0001-2490-2514)
- Lei Ni (ORCID: https://orcid.org/0009-0008-2917-0691)
- Fei Duan (ORCID: https://orcid.org/0000-0002-6490-0855)
- Xu Bingfa
- Zhengkun Xu (ORCID: https://orcid.org/0009-0004-1229-1471)
- Mengyang Li (ORCID: https://orcid.org/0000-0003-0853-6742)
Institutions
- Anhui Medical University (CN)
- Ministry of Education (KN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1007/s10565-024-09940-y
- Citations
- 2
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China