Clinical measures in chronic neuropathic pain are related to the Kennedy and endocannabinoid pathways
Endocannabinoid levels, expression of genes related to endocannabinoid metabolism, age, sex, depression and anxiety state together were strong predictors of CNP. The observed molecular changes indicate that lipid metabolism is altered in CNP and thus may represent a viable target for novel analgesics or biomarker development.
Authors
- Barira Islam (ORCID: https://orcid.org/0000-0001-5882-6903)
- Patrick McHugh (ORCID: https://orcid.org/0000-0003-0661-919X)
- Eva González‐Suárez (ORCID: https://orcid.org/0000-0003-0858-8171)
- John Stephenson (ORCID: https://orcid.org/0000-0002-7902-1837)
- David P. Finn (ORCID: https://orcid.org/0000-0001-6186-621X)
- Stephanie Bourke (ORCID: https://orcid.org/0000-0003-3995-8286)
Institutions
- University of Huddersfield (GB)
- University Hospital Galway (IE)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1111/eci.14351
- Citations
- 3
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- British Pain Society
- Pain Relief Foundation
- University of Galway
- Irish Research Council