Study the efficacy of silver nanoparticles in enhancing tracheal anastomosis healing in rabbits model

This research intended to explore the effect of nano-silver particles on healing anastomosis site in the trachea. Thirty healthy male rabbits were randomly split into control and treated groups equally for this object. Then the rabbits were anesthetized with a mixture of 30 mg/kg B.W (5%) Ketamine and 15 mg/kg B.W of (2%) Xylazine. In the control group, rabbits were induced with tracheal resection and anastomosis. While, rabbits in the treatment group, were induced with the same tracheal resection and anastomosis, a solution containing silver nanoparticles was infiltrated around the anastomosis site, and clinical and histopathological examinations investigated the animals. Clinically all animals had no clinical respiratory illness such as pneumonia, cough, or subcutaneous emphysema, which may occur due to surgical operations. In the control group severe inflammation, which included swelling, pain and redness were seen compared to those of the treated group. The histopathological evaluation of the control group was characterized by granulation tissue and angiogenesis around the suture material with hyperplasia and hypertrophy of goblet cells. Also, there was an intense inflammatory reaction in the mucosa and the presence of normal cartilage with necrosis of the tracheal gland. In the treated group, it was characterized by the development of granulation tissue with angiogenesis and inflammatory cell infiltration with hyperplasia of goblet cells and congestion of blood vessels and normal columnar epithelial cells in mucosa. To summarize, the treatment group's tracheal repair was quicker than to the change in control group.