Drug-resistant <i>BRA</i>F V600E-mutant recurrent pleomorphic xanthoastrocytoma, CNS WHO Grade 3 successfully resolved with incidental discontinuation of combined BRAF and MEK inhibitor therapy
This case study provides important insights into novel treatment strategies and their underlying mechanisms for gliomas with <i>BRAF</i> mutations.
Authors
- Akitake Mukasa (ORCID: https://orcid.org/0000-0001-7776-9086)
- Naoki Shinojima (ORCID: https://orcid.org/0000-0003-3352-7936)
- Jun‐ichiro Kuroda (ORCID: https://orcid.org/0000-0003-3912-4054)
- Y. Takeshima
- Hirotaka Inoue (ORCID: https://orcid.org/0000-0003-0626-3306)
- Yutaka Fujioka (ORCID: https://orcid.org/0000-0002-8506-9343)
- Daiki Yoshii (ORCID: https://orcid.org/0000-0003-2519-7711)
- Hiroyuki Sueyoshi (ORCID: https://orcid.org/0000-0002-0780-5384)
- Nobuhiro Hata (ORCID: https://orcid.org/0000-0002-5523-7166)
- Kuniko Sunami (ORCID: https://orcid.org/0000-0002-7137-5649)
- Kenji Fujimoto (ORCID: https://orcid.org/0000-0003-2920-4990)
- Yoshiki Mikami (ORCID: https://orcid.org/0000-0002-5759-6736)
- Masahiro Mizoguchi (ORCID: https://orcid.org/0000-0001-7690-2586)
- Hideo Nakamura (ORCID: https://orcid.org/0000-0003-2944-234X)
Institutions
- Kurume University (JP)
- Kyushu University (JP)
- Oita University (JP)
- National Kyushu Medical Center (JP)
- Kumamoto University Hospital (JP)
- National Cancer Center Hospital East (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Surgical Neurology International
- Published
- 2024-11-15
- DOI
- https://doi.org/10.25259/sni_734_2024
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.44